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CASE REPORT
Year : 2020  |  Volume : 16  |  Issue : 1  |  Page : 38-41

Chronic Diarrhoea associated with Sacubitril-Valsartan use in an Elderly Female - The Benefits of Unprescribing


1 MD, Department of Geriatric Medicine, Institute of Medical Sciences, BHU, Varanasi, UP, India
2 MBBS, Department of Pharmacology, Institute of Medical Sciences, BHU, Varanasi, UP, India
3 MD, PhD, Deptt. of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India
4 MD, Deptt. of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India

Correspondence Address:
Upinder Kaur
Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.35262/jiag.v16i1.38-41

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Sacubitril/Valsartan is a novel Angiotensin Receptor Blocker-Neprilysin Inhibitor (ARNI) approved for the treatment of patients with NYHA class II-IV Heart failure with reduced ejection fraction (HFrEF). Hypotension, renal dysfunction, upper respiratory tract infections and angioedema are the common adverse effects reported with sacubitril/valsartan. Here, we report the first case of chronic non-resolving diarrhoea refractory to conventional therapy in an elderly female on sacubitril-valsartan treatment, which posed a diagnostic challenge. The case highlights the importance of suspecting novel drugs being sparsely used in the elderly population as the aetiology of new symptoms, and conducting a therapeutic de-challenge even in the face of apparently low causality scores.


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