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ORIGINAL ARTICLE
Year : 2017  |  Volume : 13  |  Issue : 2  |  Page : 52-61

Reciprocal Expression of Myostatin and Vitamin D Receptors in Sarcopenia


1 Medical Biochemistry & Molecular Biology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt, 11381, Egypt
2 Geriatrics & Gerontology Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt, 11381, Egypt

Correspondence Address:
Amal Mansour
Medical Biochemistry & Molecular Biology, Faculty of Medicine-Ain Shams University, Biochemistry Department, Abbassia, Cairo
Egypt
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Source of Support: None, Conflict of Interest: None


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Background: Sarcopenia is the loss of skeletal muscle mass and strength or/and performance that occurs in concert with biological aging. Objectives: To evaluate both myostatin (MST) and vitamin D3 receptor (VDR) genes expression in Egyptian adults with their relation to each other and muscle state. Methods: Two groups were involved; group A of sarcopenic patients and group B of non-sarcopenic subjects. Multiplex quantitative RT-PCR for MST and VDR mRNA in the peripheral lymphocytes of sarcopenic and non-sarcopenic (control) groups subjects was done. Results: There was an inverse relationship between expression of myostatin and vitamin D3 receptor genes (r = -0.345, P = 0.014). Both MSTN and VDR showed a significant positive and negative association with muscle state respectively (p<0.001). Conclusion: The reciprocal MSTN and VDR expression reflect their role in the regulation of muscle state, which opens a new challenge for them as preventive and therapeutic targets for sarcopenia.


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