| ORIGINAL ARTICLE |
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| Year : 2017 | Volume
: 13
| Issue : 2 | Page : 52-61 |
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Reciprocal Expression of Myostatin and Vitamin D Receptors in Sarcopenia
Ghada M Gamal El- din1, Amal Mansour1, Randa Ail Labib1, Sarah A Hamza2, Fawzia Khalil1
1 Medical Biochemistry & Molecular Biology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt, 11381, Egypt
2 Geriatrics & Gerontology Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt, 11381, Egypt
Correspondence Address:
Amal Mansour
Medical Biochemistry & Molecular Biology, Faculty of Medicine-Ain Shams University, Biochemistry Department, Abbassia, Cairo
Egypt
 Source of Support: None, Conflict of Interest: None
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Background: Sarcopenia is the loss of skeletal muscle mass and strength or/and performance that occurs in concert with biological aging.
Objectives: To evaluate both myostatin (MST) and vitamin D3 receptor (VDR) genes expression in Egyptian adults with their relation to each other and muscle state.
Methods: Two groups were involved; group A of sarcopenic patients and group B of non-sarcopenic subjects. Multiplex quantitative RT-PCR for MST and VDR mRNA in the peripheral lymphocytes of sarcopenic and non-sarcopenic (control) groups subjects was done.
Results: There was an inverse relationship between expression of myostatin and vitamin D3 receptor genes (r = -0.345, P = 0.014). Both MSTN and VDR showed a significant positive and negative association with muscle state respectively (p<0.001).
Conclusion: The reciprocal MSTN and VDR expression reflect their role in the regulation of muscle state, which opens a new challenge for them as preventive and therapeutic targets for sarcopenia.
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